A low power smart temperature sensor followed by an SC amplifier and a 12bit Successive-Approximation analogue-digital converter (ADC) to compensate temperature deviation in drug electrochemical detection, is here presented. The proposed design is accurate within 0.1°C over the temperature range of -55°C to 125°C. A PTAT voltage is used for temperature monitoring. The succeeding ADC digitizes the output with a bit-clock of 50-kHz. The ADC has a Figure-of-Merit of 66 fJ/conversion-step. The system is implemented in an NXP CMOS 0.14µm technology. The die area is 0.21 mm2 and the whole system consumes less than 16µW for 1.2V of voltage supply.