Malaria is a leading parasitic disease endangering the lives of half of the world’s population. Microfluidics paves way to indispensable portable sensors to enable early sensing hence defends lives. In this paper, we demonstrate a portable sensor based on dielectric spectroscopy capable of pre-treatment and malaria parasite detection. The complete sensor system consists of a microfluidic chip connected to portable impedance circuit board, which measures the dielectric value of blood cells to detect the infection.